Genetic polymorphisms associated with intervertebral disc degeneration
نویسندگان
چکیده
منابع مشابه
Intervertebral Disc Dynamics and Degeneration
Degenerative disc disease is a serious health problem worldwide, whose etiological basis – mechanical stimulus, biochemical changes, or natural aging – is poorly understood. While the disc’s known function is that of dynamic shock absorber, its dynamic response has not been fully characterized throughout the disc health spectrum (from healthy to degenerate). Therefore, this study aimed to corre...
متن کاملDegeneration of the intervertebral disc
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
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Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between r...
متن کاملAssociation of COL2A and Aggrecan polymorphisms with the susceptibility of intervertebral disc degeneration
Background: To explore the association of COL2A and Aggrecan polymorphisms and the susceptibility of intervertebral disc degeneration (IVDD). Methods: IVDD patients (n = 354) in Spinal Surgery department of our hospital between June 2010 and June 2013 were allocated to the case group. Healthy people (n = 310) were allocated to the control group. The distribution frequency of COL2A and Aggrecan ...
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Degenerative spinal disorders including low back pain are one of the most common and costly problems for modern society. It has been recognized that these disorders are directly or indirectly associated with intervertebral disc degeneration. The disc is a cartilaginous connective tissue, composed of the nucleus pulposus(NP), annulus fibrosus and endplates, which connects adjacent vertebrae (the...
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ژورنال
عنوان ژورنال: The Spine Journal
سال: 2013
ISSN: 1529-9430
DOI: 10.1016/j.spinee.2013.01.041